La théorie de l’Entonnoir d’Intelligence Pharmacologique comme un nouveau paradigme intégratif pour la traduction du savoir traditionnel en phytomédicaments standardisés
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Résumé
Le savoir médical traditionnel, en particulier dans les régions à forte biodiversité comme la République Démocratique du Congo, représente le
résultat cumulatif de plusieurs siècles d’expérimentation empirique. Malgré sa forte valeur informationnelle, ce savoir demeure largement exclu
des systèmes de santé modernes en raison du manque de rigueur scientifique, de validation mécanistique et de standardisation. Cet article
propose un cadre conceptuel original, dénommé Entonnoir d’Intelligence Pharmacologique (EIP), qui explique comment le savoir traditionnel
peut être transformé de manière systématique en phytomédicaments standardisés. Ce cadre intègre, dans un processus séquentiel de filtration,
la documentation ethnobotanique, la modélisation moléculaire in silico et la validation biologique expérimentale, réduisant progressivement
l’incertitude tout en augmentant la robustesse scientifique. En positionnant le savoir traditionnel comme un point d’entrée intelligent plutôt que
comme un obstacle, ce modèle offre une voie vers l’innovation pharmaceutique locale, la réponse aux besoins de santé publique et le
renforcement de la souveraineté sanitaire dans les pays à revenu faible et intermédiaire.
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