Usages ethnobotaniques, composition phytochimique, activités pharmacologiques et toxicité de Hymenocardia acida Tul. : revue systématique
Mots-clés :
Hymenocardia acida, ethnobotanique, activités pharmacologiques, revue systématique, PRISMARésumé
Hymenосаrdia acidа Tul. еst un arbuste оriginaire d'Afrique, recоnnu pоur ses appliсatiоns en médeсinе traditiоnnelle, оù il еst utilisé pоur
trаiter divеrs prоblèmеs dе santé, nоtаmmеnt lеs trоublеs digеstifs, les malаdiеs métabоliques, ainsi quе les infeсtiоns еt lеs pathоlоgies
sanguines. Cettе rеvue systématique, réalisée selоn les directivеs PRISMA 2020, а analysé des dоnnées pоrtant sur l'ethnоbоtanique, la
phytоchemiе, la pharmaсоlоgiе et lа tохiсоlоgiе, publiéеs entre 2000 еt 2026. Sur un tоtаl dе 802 référencеs ехаminéеs, 42 études оriginales
оnt été rеtenuеs. Les usagеs traditiоnnеls idеntifiés incluеnt le traitement de la diarrhée, du diabètе, dе l'hypertеnsiоn, dе la drépаnосytоsе, du
paludisme, ainsi quе diverses аffectiоns cutanéеs. Lеs recherсhеs еn phytосhеmiе оnt révélé une large variété dе métabоlitеs seсоndaires, tеls
quе les flаvоnоïdеs, les tanins, lеs alсalоïdes, les sapоnines, les tritеrpénоïdes еt les stérоïdеs. Certains de сes cоmpоsés, соmmе la lutéоlinе, lе
lupeоl et le β-sitоstérоl, sоnt аssосiés à dеs activités biоlоgiquеs spéсifiques. Les études pharmaсоlоgiques mettent en évidence dеs еffеts
significatifs, nоtamment des prоpriétés antiохydantes, antibaсtériennes, anti-inflammatоirеs, аntidiabétiques, antihypеrtensеurs,
аntiсоnvulsivаntes еt anticаncérеuses, sоulignаnt ainsi le pоtentiеl thérapeutiquе dе сеtte plantе. Les dоnnées tохiсоlоgiquеs suggèrent une
tоlérаnсe générаlement sаtisfaisante, biеn que des signes de tохicité hépatiquе et reprоductive puissent apparaîtrе à dеs dоses élevéеs оu selоn
la méthоde d'аdministratiоn. En соnclusiоn, Hymenосardia аcida apparaît соmmе une ressоurcе médicinalе prоmеtteuse, mais l'hétérоgénéité
dеs méthоdes еt l'absеnce d'еssais cliniquеs sоulignеnt la nécessité de mеnеr des rесherсhеs standardiséеs еt dеs évaluаtiоns cliniquеs
apprоfоndies pоur cоnfirmеr sоn efficacité et sa sécurité.
Téléchargements
Références
Abu, A., & Uchendu, C. (2010). Antispermatogenic
effects of aqueous ethanolic extract of
Hymenocardia acida stem bark in Wistar rats.
Journal of Medicinal Plants Research, 4(23),
2495–2502. https://doi.org/10.5897/JMPR10.407
Abu, A., & Uchendu, C. (2011). In vivo trypanocidal
activity of hydroethanolic extract of Hymenocardia
acida stem bark in rats. Veterinary World, 4(3),
113–116. https://doi.org/10.5455/VETWORLD.2011.113-
116
Adedokun, O., Ntungwe, E., Viegas, C., Ayinde, B.,
Barboni, L., Maggi, F., Saraiva, L., Rijo, P., &
Fonte, P. (2022). Enhanced anticancer activity of
Hymenocardia acida stem bark extract loaded into
PLGA nanoparticles. Pharmaceuticals, 15(5), 535.
https://doi.org/10.3390/ph15050535
Adomou, A., Yedomonhan, H., Djossa, B., Legba, S.,
Oumorou, M., & Akoegninou, A. (2012). Étude
ethnobotanique des plantes médicinales vendues
dans le marché d’Abomey-Calavi au Bénin.
International Journal of Biological and Chemical
Sciences, 6(2), 745–772.
Apema, R., Mozouloua, D., Kosh-Komba, E., &
Ngoule, Y. (2011). Les plantes médicinales
utilisées dans le traitement de l’hypertension
artérielle par les tradipraticiens à Bangui.
[Référence incomplète : source de publication
non fournie.]
Arsène, M., Akouasso, A., Koffi, S., Soro, T., &
Kouakou, K. (2025). Phytochemical study and
evaluation of the effect of aqueous extract from the
roots of Hymenocardia acida (Euphorbiaceae) on
sexual behaviour in diabetic Wistar rats. Scholars
Academic Journal of Biosciences, 13(11), 1500–
1507.
https://doi.org/10.36347/sajb.2025.v13i11.003
Bruschi, P., Morganti, M., Mancini, M., & Signorini,
M. (2011). Traditional healers and laypeople: A
qualitative and quantitative approach to local
knowledge on medicinal plants in Muda
(Mozambique). Journal of Ethnopharmacology,
138, 543–563.
Catarino, L., Havik, P., & Romeiras, M. (2016).
Medicinal plants of Guinea-Bissau: Therapeutic
applications, ethnic diversity and knowledge
transfer. Journal of Ethnopharmacology, 183, 71–
94.
Chukwuemeka, N., Adejoh, I., Osafanme, I., &
Chizoba, A. (2018). Ameliorative effect of
methanol extract of Hymenocardia acida leaves on
gentamicin-induced renal toxicity in rats. Asian
Journal of Research in Biochemistry, 3(2), 1–9.
https://doi.org/10.9734/AJRB/2018/V3I229818
Ezeigbo, I., & Asuzu, I. (2012). Anti-diabetic activities
of the methanol leaf extracts of Hymenocardia
acida (Tul.) in alloxan-induced diabetic rats.
African Journal of Traditional, Complementary
and Alternative Medicines, 9(2), 204–209.
https://doi.org/10.4314/AJTCAM.V9I2.4
Ezuruike, U., & Prieto, J. (2014). The use of plants in
the traditional management of diabetes in Nigeria:
Pharmacological and toxicological considerations.
Journal of Ethnopharmacology, 155, 857–924.
Frazão-Moreira, A. (2016). The symbolic efficacy of
medicinal plants: Practices, knowledge, and
religious beliefs amongst the Nalu healers of
Guinea-Bissau. Journal of Ethnobiology and
Ethnomedicine, 12, 24.
Göhre, Á ., Toto-Nienguesse, B., Futuro, M., Neinhuis,
C., & Lautenschläger, T. (2016). Plants from
disturbed savannah vegetation and their usage by
Bakongo tribes in Uíge, Northern Angola. Journal
of Ethnobiology and Ethnomedicine, 12, 42.
Hooijmans, C., Rovers, M., de Vries, R., Leenaars, M.,
Ritskes-Hoitinga, M., & Langendam, M. (2014).
L’outil de risque de biais de SYRCLE pour les
études animales. BMC Medical Research
Methodology, 14, 43. https://doi.org/10.1186/1471-
2288-14-43
Igoli, J., & Gray, A. (2008). Friedelanone and other
triterpenoids from Hymenocardia acida.
International Journal of Physical Sciences, 3(6),
156–158.
Koffi, S., Soro, T., Bégbin, K., Abizi, G., Ahebié, M.,
Kouadio, K., Zougrou, N., & Kouakou, K. (2022).
Acute and subchronic toxicities of the aqueous
extract of the Hymenocardia acida
(Euphorbiaceae) roots in rodents. European
Journal of Medicinal Plants, 33(1), 39–48.
https://doi.org/10.9734/ejmp/2022/v33i130444
Koné, W., Kamanzi, A., Terreaux, C., Hostettmann, K.,
Traoré, D., & Dosso, M. (2004). Traditional
medicine in North Côte-d’Ivoire: Screening of 50
medicinal plants for antibacterial activity. Journal
of Ethnopharmacology, 93, 43–49.
Lautenschläger, T., Monizi, M., Pedro, M., Mandombe,
J., Futuro, B., Heinze, C., & Neinhuis, C. (2018).
First large-scale ethnobotanical survey in the
province of Uíge, northern Angola. Journal of
Ethnobiology and Ethnomedicine, 14, 51.
Magassouba, F., Dialloa, A., Kouyaté, M., Mara, F.,
Bangoura, O., Camara, A., Traoré, S., Diallo, A.,
Zaoro, M., Lamah, K., Diallo, S., Camara, G.,
Traoré, S., Kéita, A., Camara, M., Barry, R., Kéita,
S., Oularé, K., Barry, M., . . . Baldé, A. (2007).
Ethnobotanical survey and antibacterial activity of
some plants used in Guinean traditional medicine.
Journal of Ethnopharmacology, 114, 44–53.
Makumbelo, E., Lukoki, L., Paulus, J., & Luyindula,
N. (2008). Stratégie de valorisation des espèces
ressources des produits non ligneux de la savane
des environs de Kinshasa : II. Enquête
ethnobotanique (aspects médicinaux).
Tropicultura, 26(3), 129–134.
Malebo, N., Manduna, I., Mawunu, M., Chokwe, R., &
Tlhapi, B. (2025). Identification of antioxidant,
antimicrobial, and cytotoxic compounds from
Hymenocardia acida Tul. using ultra-highperformance liquid chromatography-quadrupole
Exactive-Orbitrap-mass spectrometry and
molecular networking approach. Chemistry &
Biodiversity, 23(2), e02485.
https://doi.org/10.1002/cbdv.202502485
Maliwichi-Nyirenda, C., & Maliwichi, L. (2010).
Medicinal plants used for contraception and
pregnancy-related cases in Malawi: A case study of
Mulanje. Journal of Medicinal Plants Research,
4(20), 2121–2127.
Manga, F., Khattabi, C., Fontaine, J., Berkenboom, G.,
Duez, P., Noyon, C., Van Antwerpen, P., Lami
Nzunzu, J., & Pochet, S. (2013). Vasorelaxant and
antihypertensive effects of methanolic extracts
from Hymenocardia acida Tul. Journal of
Ethnopharmacology, 146(2), 623–631.
https://doi.org/10.1016/j.jep.2013.02.002
Mathieu, M., Ojong, L., Omam, Ngo Bum, E., Tembe
Achick, E., Ahouga, R., Chindje, H., Nfogham, N.,
Tayou, P., Fonyuy, M.-C., Mbacham, W., &
Fokunang, C. (2024). Evaluation of the antioxidant
capacity and studies of the anticonvulsant
properties of Hymenocardia acida. Journal of
Advances in Biology & Biotechnology, 27(3), 129–
139. https://doi.org/10.9734/jabb/2024/v27i3728
Nanfack, D., Metiave, A., Dongmo, F., Lateef, M.,
Awouafack, M., Ngouela, S., Ali, M., & Tene, M.
(2024). Secondary metabolites from the leaves of
Hymenocardia acida and their chemotaxonomic
significance. Biochemical Systematics and
Ecology.
https://doi.org/10.1016/j.bse.2024.104799
Ndako, J. A., Tijani, S. D., Oyekanmi, B. A., Ayodele,
S. I., Onuchukwu, E. O., Yeye, E. O., Ohiobo, A.
E., Ndako, C. J., & Oniyelu, O. F. (2026).
Phytochemical, antioxidant and antimicrobial
activity of Hymenocardia acida and Phyllanthus
amarus extracts against selected clinical isolates
[Preprint]. Preprints.
https://doi.org/10.20944/preprints202606.1259.v1
Nguemo, D., Bonyo, A., Mapongmetsem, P., &
Bayegone, E. (2018). Étude ethnobotanique et
phytochimique des plantes médicinales utilisées
dans le traitement des maladies cardiovasculaires à
Moundou (Tchad). International Journal of
Biological and Chemical Sciences, 12(1), 203–216.
Obidike, I., Aboh, M., & Salawu, O. (2011).
Microbiological and mucociliary properties of the
ethanol extract of Hymenocardia acida on selected
respiratory clinical isolates. Journal of Dietary
Supplements, 8(1), 1–11.
https://doi.org/10.3109/19390211.2010.542231
Ogbunugafor, H., Sofidiya, O., Okpuzor, J., Kemdilim,
M., Anajekwe, B., & Ekechi, A. (2010). Effect of
extracts of Hymenocardia acida Tul.
(Hymenocardiaceae) on rats. Journal of American
Science, 6(2), 143–146.
Oluwasegun, A., Epole, N., Claudia, V., Bunyamin, A.,
Luciano, B., Filippo, M., Lucilia, S., Patricia, R., &
Pedro, F. (2022). Activité anticancéreuse accrue de
l’extrait d’écorce de tige d’Hymenocardia acida
encapsulé dans des nanoparticules de PLGA.
Pharmaceuticals, 15(5), 535.
Oluwasegun, A., Ogochukwu, U., Ugochukwu, O.,
Mussaddiq, I., & Bunyamin, A. (2023). Lupeol: A
triterpenoid isolated from the stem bark of
Hymenocardia acida (Tul.) exhibits a van der
Waals antagonism on the alpha subunit of gastric
H+K+ATPase—A promising antiulcer principle.
Drug Research, 73(8), 448–458.
https://doi.org/10.1055/a-2132-6475
Oni, J., Obi, C. I., Adeoluwa, G., Adeniyi, F., Jack, I.,
Otomewo, L., Okorie, O., Wakeel, O., &
Adeoluwa, O. (2026). Ethanol extract of
Hymenocardia acida Tul. (Euphorbiaceae)
ameliorates pentylenetetrazole-induced seizures
and neuroinflammation in mice. Tropical Journal
of Natural Product Research, 9(12), 6352–6355.
https://doi.org/10.26538/tjnpr/v9i12.57
Oshomoh, E., & Idu, M. (2012). Antimicrobial and
antifungal activities of ethanol and aqueous crude
extracts of Hymenocardia acida stem against
selected dental caries pathogens. Pharmacognosy
Journal, 4(29), 55–60.
https://doi.org/10.5530/PJ.2012.29.9
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron,
I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L.,
Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R.,
Glanville, J., Grimshaw, J. M., Hróbjartsson, A.,
Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E.,
McDonald, S., & Moher, D. (2021). The PRISMA
2020 statement: An updated guideline for reporting
systematic reviews. BMJ, 372, n71.
https://doi.org/10.1136/bmj.n71
Shimbe, R., Tor-anyiin, T., Khan, M., & Anyam, J.
(2016). β-Sitosterol from Hymenocardia acida root
extract and its antimicrobial activity. Journal of the
Chemical Society of Nigeria, 41(1), 76–81.
Sofidiya, M., Odukoya, O., Afolayan, A., & Familoni,
O. (2009). Phenolic contents, antioxidant and
antibacterial activities of Hymenocardia acida.
Natural Product Research, 23(2), 168–177. https://doi.org/10.1080/14786410801915838
Sofidiya, M., Lange, C., Sattler, I., Beukes, D.,
Afolayan, A., Odukoya, O., & Familoni, O. (2010).
Bioactivity profile of compounds isolated from
Hymenocardia acida Tul. leaves. Planta Medica,
76(12). https://doi.org/10.1055/S-0030-1264439
Starks, C., Williams, R., Norman, V., Rice, S., O’NeilJohnson, M., Lawrence, J., & Eldridge, G. (2014).
Antibacterial chromene and chromane stilbenoids
from Hymenocardia acida. Phytochemistry, 98,
216–222.
https://doi.org/10.1016/j.phytochem.2013.11.012
Suleiman, D., Lawal, N. B., Alhassan, A. M., Sani, Z.
I., Abubakar, N. A., Zubair, A. O., Ilyasu, S., &
Ibrahim, U. I. (2025). In-silico investigation of the antischizophrenic activity of phytochemical
constituents of Hymenocardia acida Tul.
(Phyllantaceae). Tropical Journal of Natural
Product Research, 9(3), 1309–1316.
https://doi.org/10.26538/tjnpr/v9i3.55
Tuenter, E., Exarchou, V., Baldé, A., Apers, S., &
Pieters, L. (2014). A new cyclopeptide alkaloid
from Hymenocardia acida. Planta Medica, 80(16).
https://doi.org/10.1055/s-0034-1394547
Tugume, P., Kakudidi, E., Buyinza, M., Namaalwa, J.,
Kamatenesi, M., Mucunguzi, P., & Kalema, J.
(2016). Ethnobotanical survey of medicinal plant
species used by communities around Mabira
Central Forest Reserve, Uganda. Journal of
Ethnobiology and Ethnomedicine, 12, 5.
Wada, A., Yaro, A., Aliyu, M., Danjuma, N., &
Mohammed, M. (2017). Evaluation of
anticonvulsant activities of ethanol leaf extract of
Hymenocardia acida Tul. (Euphorbiaceae) in mice
and chicks. Bayero Journal of Pure and Applied
Sciences, 10(1), 368–371.
https://doi.org/10.4314/BAJOPAS.V10I1.73S
Yakubu, O., Olawale, O., Arowora, K., & Imo, C.
(2017a). Biochemical changes in haematological
and liver function parameters in intoxicated male
albino rats treated with Hymenocardia acida leaves
ethanolic extract. Insights in Biomedicine, 2(2).
https://doi.org/10.21767/2572-5610.10026
Yakubu, O., Nwodo, O., Imo, C., & Ogwoni, H.
(2017b). Spermatogenic and haematological effects
of aqueous and ethanolic extracts of Hymenocardia
acida stem bark on aluminium-induced toxicity in
male Wistar rats. iMedPub Journals, 2, 1.
https://doi.org/10.21767/2572-5610.10017
Yakubu, Y., Ac, O., & Dawoye, Y. (2016). Effects of
ethanol extract of Hymenocardia acida leaves on
aluminium chloride-induced toxicity in male albino
rats. Journal of Analytical & Pharmaceutical
Research, 3(2), 00049.
https://doi.org/10.15406/JAPLR.2016.03.00049
Yemoa, A., Gbenou, J., Johnson, R., Djego, J., Zinsou C., Moudachirou, M., Quetin-Leclercq, J., Bigot,
A., & Portaels, F. (2008). Identification et étude
phytochimique de plantes utilisées dans le
traitement traditionnel de l’ulcère de Buruli au
Bénin. Bulletin de la Société Française
d’Ethnopharmacologie et de la Société Européenne
d’Ethnopharmacologie, 42, 50–57.
Téléchargements
Publiée
Numéro
Rubrique
Licence
(c) Copyright Tshidibi et al 2026
Ce travail est disponible sous licence Creative Commons Attribution - Pas d’Utilisation Commerciale - Partage dans les Mêmes Conditions 4.0 International.
