Review of Medicinal Plants of the Uvariodendron Genus (Annonaceae) and the Potential for Their Integration into the Agribusiness Strategy in the Democratic Republic of the Congo
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Abstract
Context: The Uvariodendron genus comprises wild plants with multiple therapeutic uses, the valorization of which could contribute to improving the management of several diseases and their integration into the national agribusiness strategy. Objective: This study aims to provide an overview of current knowledge about this genus in order to guide future research.
Methodology: A bibliographic search of articles related to Uvariodendron was conducted in various electronic databases (Science Direct, PubMed, Web of Science, Scopus, Google Scholar, SciELO, etc.), using keywords such as Uvariodendron, phytochemistry, pharmacology, and toxicology. Results and Discussion: The available literature on plants of the Uvariodendron genus indicates that they contain flavonoids, tannins, quinones, saponins, alkaloids, steroids, terpenoids, anthocyanins, etc. These plants possess anticancer, antioxidant, anti-inflammatory, antimalarial, antimicrobial, urotonic, anti-sickle cell, and other properties. Toxicological studies have shown that U. anisatum (originating from Kenya) is toxic in rats. However, U. molundense (originating from the DRC) is not cytotoxic, indicating a certain degree of safety. Conclusion and Perspectives: The results of this study demonstrate that the Uvariodendron genus could be used for various therapeutic applications. However, clinical studies are necessary to rigorously establish their effectiveness and safety. Additionally, the integration of U. molundense into the national agribusiness strategy in the DRC can contribute to the country's economic, environmental, and social sustainability while preserving its biodiversity and medicinal traditions.
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References
Dagallier MJ, Mbago MF, Quentin Luke WR, Couvreur LPT (2021). Three new species of Uvariodendron (Annonaceae) from coastal East Africa in Kenya and Tanzania. PhytoKeys 174: 107–126. doi: 10.3897/phytokeys.174.61630.
Djolu R, Masengo A, Ngbolua KN, Mawunu M, Iteku B, Tshilanda D, Tshilanda D, Mpiana P, Mudogo V (2021). Ethnobotanical study and vulnerability of Uvariodendron molundense (Annonaceae) in Gbado-Lite city (Ubangi ecoregion), Democratic Republic of the Congo. Journal of Botanical Research 3(3): 41-48.
Djolu RD, Ngbolua KN, Iteku JB, Masengo CA, Tshilanda DD, Mpiana PT (2023). Profil phytochimique, pharmaco-biologique et cytotoxique des feuilles de Uvariodendron molundense (Annonaceae). Revue Marocaine des Sciences Agronomiques et Vétérinaires 11(2): 224-235.
Fekam BF, Amvam ZHP, Agnaniet H, Menut C, Bessière JM (2015). Aromatic Plants of Tropical Central Africa. XL. Essential Oils from Uvariodendron calophyllum R.E. Fries Growing in Cameroon. Journal of Essential Oil Research 17(2): 128-129. doi: 10.1080/10412905.2005.9698852.
Kaingu KC, Oduma AJ, Mbaria J, Kiama JS (2017). Effects of Croton menyharthii and Uvariodendron kirkii extracts on ovarian corpora lutea and reproductive hormones. Discovery Phytomedicine 4(1): 21-25.
Kanji BM, Maitho ET, Wakonyu KL, Misonge OJ (2022). Evaluation of Uterotonic Activity, Acute Oral Toxicity, and Phytochemical Composition of Uvariodendron anisatum Verdc. Root Extracts. Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2022/7393537
Kihampa C, Mayunga H, Nkunya H, Cosam CJ, Magesa MS (2010). Antimosquito Phenylpropenoids from the Stem and Root Barks of Uvariodendron pycnophyllum (Diels) R.E.Fr. J. Appl. Sci. Environ. Manag. 14(3): 29-32.
Mathouet H, Sima Obiang C, Lekongo Moungomo CM, Bourobou Bourobou HP, Ondo JP (2019). Antibacterial efficacy of essential oil from leaf of Uvariodendron molundense (Annonaceae), medicinal plant of Gabon. Int. J. Biosci.15(4) : 33-39. DOI: http://dx.doi.org/10.12692/ijb/15.4.33-39.
Menkem E, Fokou J, Tsague I, Chouadeu P, Bakarnga-Via I, Kamdem M, Nya P, Fokou V, Mofor C, Fekam B (2012). Activités antifongiques et antioxydantes de Piptostigma calophyllum, Uvariodendron calophyllum et Uvariodendron molundense cultivés au Cameroun. Journal of Biologically Active Products from Nature 2(2):110-118.
Mongeke MM, Ngbolua KN, Bakola RD, Inkoto CL, Elikandani PN, Mowuli CY (2018). Survey on the plants used in Traditional medicine by Bambenga: Pygmy from Dongo Sector (Territory of Kungu, Province of Sud-Ubangi) in Democratic Republic of the Congo. Revue Marocaine des Sciences Agronomiques et Vétérinaires 6 (4): 469-475.
Ndaba MM, Djolu DR, Masengo AC, Falanga MC, Lengbiye ME, Inkoto LC, Gbolo ZB, Ridwan R, Mpiana PT, Mudogo V, Ngbolua KN (2020). Congolese Medicinal Plant biodiversity as Source of AntiCOVID-19 Compounds: Economic goods in the light of Comparative Advantages Theory of Ricardo. Budapest International Research in Exact Sciences (BirEx) Journal 2(3): 298-309. doi: https://doi.org/10.33258/birex.v2i3.1067.
Ndaba MM, Likolo JB, Bembi B, Kangu KJ, Mbaya KJ, Magbukudua M, Masengo AC, Bongo NG, Muhammad R, Ngbolua KN (2021a). COVID-19 Pandemic in Democratic Republic of the Congo: An Opportunity for Economic Recovery. Britain International of Exact Sciences (BIoEx) Journal 3(2). https://doi.org/10.33258/bioex.v3i2.434.
Ndaba MM, Mawi CF, Nyante UM, Kobe JK, Djoza RD, Magbukudua JM, Masengo MC, Bongo GN, Ridwan M, Ngbolua KN (2021b). COVID-19 Pandemic: Opportunity for a True Economic and Regional Integration of Africa. Budapest International Research in Exact Sciences (BirEx) Journal 3(2). https://doi.org/10.33258/birex.v3i2.1884.
Ngbolua KN, Inkoto CL, Mongo NL, Ashande CM, Masens YB, Mpiana PT (2019). Étude ethnobotanique et floristique de quelques plantes médicinales commercialisées à Kinshasa, République Démocratique du Congo. Revue Marocaine des Sciences Agronomiques et Vétérinaires 7(1) : 118-128.
Ngbolua KN, Tshilanda D, Djolu R, Falanga C, Masengo C, Tshibangu D, Iteku J, Mudogo V, Mpiana P (2017). Effets inhibiteurs bactériens et anti-anémie falciforme de Uvariodendron molundense (Diels) R.E.Fr. (Annonaceae) du bassin de la rivière Ubangi, RD Congo. Journal of Biosciences and Medicines 5: 71-84.
Noudogbessi JP, Gary-Bobo M, Adomou A, Adjalian E, Alitonou AG, Avlessi F, Garcia M, Sohounhloue DCK, Menut C (2014). Comparative Chemical Study and Cytotoxic Activity of Uvariodendron angustifolium Essential Oils from Benin. Natural Product Communications 9(2): 261-264.
Tajbakhsh E, Kwenti TE, Kheyri P, Nezaratizade S, Lindsay DS, Khamesipour F (2021). Antiplasmodial, antimalarial activities and toxicity of African medicinal plants: a systematic review of literature. Malaria Journal 20(1):349. https://doi.org/10.1186/s12936-021-03866-0.
WHO (World Health Organization). Traditional medicine strategy 2002-2005, 2002. http://www.who.int/medicines/library/trmtrateng.pdf.