Martial balance status (iron, ferritin, and transferrin) in artisan diggers exposed to Mining pollution in Kambove, democratic republic of Congo

Main Article Content

Arold Fazili
Tercia MPANGA
Armand ABASI
Gradine Mujinga

Abstract

Introduction: Artisanal mining in the Kambove region exposes miners to significant environmental pollution, particularly
heavy metals. This chronic exposure could lead to disruptions in iron metabolism, which is essential for many biological
functions. Biological markers such as ferritin, transferrin, and serum iron can be used to assess these potential alterations.
Objective: To assess the levels of iron metabolism markers in miners. Methods: The study involved 60 participants, including
30 miners and 30 controls. Blood samples were collected, and the concentrations of the three iron markers were analyzed in
the laboratory. Statistical comparisons between the two groups were performed using Student's t-test. Results: The results
show significantly elevated ferritin in miners (356.75 μg/L) compared to controls (129.33 μg/L), and significantly lower
serum iron (59.43 μg/dL vs. 100.65 μg/dL). Transferrin did not show a significant difference between the two groups.
Conclusion: We concluded that environmental pollution in mining areas could negatively influence iron regulation in exposed
workers, posing a real public health problem in these environments.

Article Details

Section

Articles

References

Baker, R. D., Greer, F. R. et Comité de nutrition

(2020) « Diagnostic et Préventions de la carence

en fer et de l’anémie ferriprive chez les

nourrissons et les jeunes enfants », Pediatrics,

(5), pp. 1040 1050

Bossuyt X. Et Boynaems, J. Repères en diagnostic de

laboratoire, Garant, Louvain, 2001.

Bouyer, J. : « Méthodes statistiques, Médecine -

Biologie ». ESTEM, Editions INSERM, Paris,

Clark, D. C., Williams, M. K. et Basha, O. M. (2021)

« Impacts environnementaux de l’exploitation

minière artisanale », Environmental Health

Perspectives, 129(3), 035001.

Cobbina, S. J. et al. (2015) « Évaluation de la toxicité

liée à une exposition subchronique à quatre

métaux lourds », Journal of Hazardous

Materials, 294, pp. 109 120 9.

Engo, B.G. Cours de chimie medicale, istm

Lubumbashi, Lubumbashi 2010.

Henry, J.B., et. al., Clinical Diagnosis and

Management by Laboratory Methods,

Nineteenth Edition, WB Saunders, 1996.

Kaplan A et al. Clin chem the CV mosby Co. St

Louis. Toronto Princeton 1984,1063-1065.

Leblanc M, Malaise F. : Lubumbashi, un écosystème

urbain tropical,CIS/UNAZA, Campus de

Lubumbashi, Lubumbashi, 1978

Marshal W.J. et Bengert S.K. Biochimie médicale,

Physiopathologie etdiagnostic, Elsevier, Paris,

Mbayo, L., Tshikala, D. et Kasongo, J. (2021) « Étude

de l’élévation de la ferritine sérique chez les

ouvriers miniers exposés aux activités minières à Kolwezi », Revue Congolaise de Santé Publique,

(1), pp. 66–74

Mulenga, E., Kalaba, J. et Phiri, D. (2019) «

Évaluation des effets de l’exposition au cobalt et

au cuivre sur les marqueurs du métabolisme du

fer chez les mineurs en Zambie », Journal

Africain de Médecine du Travail, 11(3), pp. 145–

Ndibualonji Bb. V. Cours de chimie medicale, istm

lubumbashi, lubumbashi, 2013.

Pesce, A.J., Kaplan, L.A., Methods in Clinical

Chemistry, CV Mosby Co., 1987

Schwartz, D. : « Méthodes statistiques à l’usage des

médecins et des biologistes », Edition

Flammarion – Médecine- Sciences, 15ème

tirages, Paris, 2010.

Shu Qiang, Zhang Man. Application of ferritin

detection in Clinic labeled immunoassay and

clinic, December 2012, Volume 19(6):378-379.

Tampushi, Y., Kabwe, C. et Mumba, M. (2022) «

Pollution minière artisanale dans le HautKatanga

», African Journal of Environmental Science and

Technology, 16(3), pp. 117 128Tampushi, Y.,

Kabwe, C. et Mumba, M. (2022) « Pollution minière

artisanale dans le HautKatanga », African

Journal of Environmental Science and

Technology, 16(3), pp. 117 128

Tietz N W et al. Clinical guide to labortaory tests, 3rd

ed AACC, 1995

Valdiguie, P. Biochimie Clinique, Université Paul

Sebastier, Toulouse, 2000

Wheinan S. Toute la Biochimie, Dunod, Paris, 2004

Zhu Lan, Zhan Yan, Hang Biao, Guo Ming Ming,

Dong Xiaoli. Establishment and clinical

application of ferritin time-resolved

immunofluorescence chromatography. Modern

immunology, vol 36(1):50-53.

Similar Articles

You may also start an advanced similarity search for this article.